Thiazides for kidney stones


Generic Name Brand Name
chlorthalidone Thalitone
hydrochlorothiazide Microzide, Oretic

How It Works

Thiazides reduce the amount of calcium in the urine, which may prevent calcium kidney stones.

Why It Is Used

Thiazides may prevent the formation of calcium kidney stones, especially if changing your diet and drinking more fluids have not helped.

How Well It Works

People who take thiazides get fewer than half as many calcium stones as they did before taking this medicine.1

Side Effects

Possible side effects of thiazides include:

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

You can prevent lower levels of potassium in the blood by taking potassium citrate with the thiazide.

Eating too much salt reduces the effect of thiazides.

Use of thiazides for kidney stones is an unlabeled use of these medicines. But doctors have found that thiazides safely and effectively prevent kidney stones in some people.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.



  1. Spector DA (2007). Urinary stones. In NH Fiebach et al., eds., Principles of Ambulatory Medicine, 7th ed., pp. 754–766. Philadelphia: Lippincott Williams and Wilkins.

Last Updated: May 4, 2009

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