Hepatitis B immune globulin (HBIG)

Hepatitis B immune globulin (HBIG) is a solution of antibodies that are capable of attaching to and preventing the hepatitis B virus from infecting liver cells.

An injection of HBIG may help prevent HBV infection if it is given within 14 days of exposure to the virus when you:

  • Have not been immunized against HBV but have come in contact with the blood or body fluids (semen or vaginal fluids, including menstrual blood) of someone who has hepatitis B.
  • Are being immunized against HBV but have not yet received all three shots in the vaccination series and are exposed to the virus. In most cases, HBIG will prevent infection until the vaccine takes effect.

HBIG is safe for women who are pregnant or breast-feeding.

HBIG is prepared from blood products obtained from human donors. Human immunodeficiency virus (HIV), the virus that causes AIDS, has never been transmitted by HBIG.

Last Updated: August 6, 2009

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