Corticobasal Degeneration

National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Corticobasal Degeneration is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • Cortical-Basal Ganglionic Degeneration
  • Cortico-Basal Ganglionic Degeneration (CBGD)
  • CBGD

Disorder Subdivisions

  • None

General Discussion

Corticobasal degeneration is a rare progressive neurological disorder characterized by cell loss and shrinkage (atrophy) in certain areas of the brain (cerebral cortex and substantia nigra). Affected individuals may have sufficient muscle power for manual tasks but often have difficulty directing their movements appropriately. Initial symptoms typically appear in people during the sixth decade, and may include poor coordination, difficulty accomplishing goal-directed tasks (e.g., buttoning a shirt), and/or difficulty pantomiming actions. Symptoms usually begin on one side of the body (unilateral), but both sides may be affected as the disease progresses. Cognitive impairment (e.g., memory loss) and/or visual-spatial impairments may also occur. The exact cause of corticobasal degeneration is unknown.


WE MOVE (Worldwide Education and Awareness for Movement Disorders)
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CurePSP: Society for Progressive Supranuclear Palsy
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National Institute of Neurological Disorders and Stroke (NINDS)
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Genetic and Rare Diseases (GARD) Information Center
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UCSF Memory and Aging Center
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Association for Frontotemporal Dementias (AFTD)
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For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see

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