National Organization for Rare Disorders, Inc.
It is possible that the main title of the report MURCS Association is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Mullerian Duct Aplasia-Renal Aplasia-Cervicothoracic Somite Dysplasia
- Mullerian-Renal-Cervicothoracic Somite Abnormalities
- Mullerian Duct-Renal-Cervicothoracic-Upper Limb Defects
- Mullerian Duct and Renal Agenesis with Upper Limb and Rib Anomalies
MURCS association is a very rare developmental disorder that affects only females. The acronym MURCS stands for (MU)llerian, (R)enal, (C)ervicothoracic (S)omite abnormalities. This rare disorder is characterized by the absence of the uterus, cervix, and upper part of the vagina (mullerian aplasia); kidney (renal) abnormalities, including absent (agenic) and/or improperly positioned (ectopic) kidneys; and/or malformations of the spinal column, ribs, and/or arms. Some affected females may exhibit additional physical abnormalities, such as malformations of the head and facial (craniofacial) area. In individuals with MURCS association, symptoms vary from case to case.
MURCS association appears to occur randomly, with no apparent cause (sporadic). Some researchers suggest that the malformations associated with this disorder may result from abnormal changes in cellular material (blastema) in portions of the embryo that later develop into the arms, certain bones (vertebrae) in the spinal column, the kidneys, and adjacent structures (e.g., fallopian tubes).
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This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html