Membranoproliferative Glomerulonephritis Type II

National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Membranoproliferative Glomerulonephritis Type II is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • MPGN type II
  • dense deposit disease

Disorder Subdivisions

  • None

General Discussion

Membranoproliferative glomerulonephritis type II (MPGN2) is one of three related types of a disease of the tiny filtering mechanism (glomeruli) of the kidney. The disease is probably autoimmune, although just what triggers the immune system to generate an autoimmune response is not known.

The glomeruli are the part of the internal kidney structures where the blood flows through very small capillaries and is filtered through membranes to form urine. When this disease is present, deposits of immune materials spread through the membranes leading to a thickening of the capillary walls, and therefore disrupting the kidney function.

Levels of some blood proteins related to the immune system (blood "complements") are altered in membranoproliferative glomerulonephritis. In particular, levels of some specific complement proteins are very low in the blood. This condition is referred to as "hypocomplementemia". In addition, blood may be found in the urine (hematuria), as well as proteins not normally found in urine samples (proteinuria).

Damage to the glomeruli is progressive, leading in most cases to kidney failure and to long-term kidney dialysis or to kidney transplantation.


National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Tel: (212)889-2210
Fax: (212)689-9261
Tel: (800)622-9010

The Greater Cedar Rapids Community Foundation
200 First Street, S.W.
Cedar Rapids, IA 52404

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223

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This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see

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