CADASIL

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report CADASIL is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Cerebral AutoDom Arteriopathy w/Subcortical Infarcts & Leukoencephalopathy
  • Hereditary Multi-Infarct Dementia

Disorder Subdivisions

  • None

General Discussion

Synonyms:
Hereditary Multi-Infarct Dementia
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts
and Leukoencephalopathy

CADASIL is a rare genetic disorder that causes multiple strokes in adults, even young adults, often without cardiovascular risk factors. CADASIL often progresses to cause cognitive impairment and dementia. The symptoms of CADASIL result from damage of various small blood vessels, especially those within the brain. The age of onset, severity, specific symptoms and disease progression varies greatly from one person to another, even among members of the same family. CADASIL is an acronym that stands for:

• (C)erebral – relating to the brain (A)utosomal (D)ominant – a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder.
• (A)rteriopathy – disease of the small arteries (blood vessels that carry blood away from the heart).
• (S)ubcortical – relating to a specific area of the deep brain that is involved in higher functioning (e.g., voluntary movements, reasoning, memory).
• (I)nfarcts – tissue loss in the brain caused by lack of oxygen to the brain, which occurs when blood flow in the small arteries is blocked or abnormal.
• (L)eukoencephalopathy – destruction of the myelin, an oily substance that covers and protects nerve fibers in the central nervous system.
.

Resources

United Leukodystrophy Foundation
2304 Highland Drive
Sycamore, IL 60178
Tel: (815)895-3211
Fax: (815)895-2432
Tel: (800)728-5483
Email: office@ulf.org
Internet: http://www.ulf.org/

National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Email: me20t@nih.gov
Internet: http://www.ninds.nih.gov/

CADASIL-Together We Have Hope
3605 Monument Dr
Round Rock, TX 78681
USA
Tel: (512)255-0209
Fax: (512)255-0209
Tel: (877)467-3669
Email: cadasil@earthlink.net OR info@cadasilfoundation.org
Internet: http://cadasilfoundation.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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