National Organization for Rare Disorders, Inc.
It is possible that the main title of the report CADASIL is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Cerebral AutoDom Arteriopathy w/Subcortical Infarcts & Leukoencephalopathy
- Hereditary Multi-Infarct Dementia
Hereditary Multi-Infarct Dementia
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts
CADASIL is a rare genetic disorder that causes multiple strokes in adults, even young adults, often without cardiovascular risk factors. CADASIL often progresses to cause cognitive impairment and dementia. The symptoms of CADASIL result from damage of various small blood vessels, especially those within the brain. The age of onset, severity, specific symptoms and disease progression varies greatly from one person to another, even among members of the same family. CADASIL is an acronym that stands for:
• (C)erebral – relating to the brain (A)utosomal (D)ominant – a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder.
• (A)rteriopathy – disease of the small arteries (blood vessels that carry blood away from the heart).
• (S)ubcortical – relating to a specific area of the deep brain that is involved in higher functioning (e.g., voluntary movements, reasoning, memory).
• (I)nfarcts – tissue loss in the brain caused by lack of oxygen to the brain, which occurs when blood flow in the small arteries is blocked or abnormal.
• (L)eukoencephalopathy – destruction of the myelin, an oily substance that covers and protects nerve fibers in the central nervous system.
United Leukodystrophy Foundation
2304 Highland Drive
Sycamore, IL 60178
National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
CADASIL-Together We Have Hope
3605 Monument Dr
Round Rock, TX 78681
Email: email@example.com OR firstname.lastname@example.org
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This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html