Arthrogryposis Multiplex Congenita

National Organization for Rare Disorders, Inc.

It is possible that the main title of the report Arthrogryposis Multiplex Congenita is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • AMC
  • Congenital Multiple Arthrogryposis
  • Fibrous Ankylosis of Multiple Joints
  • Multiple congenital contractures

Disorder Subdivisions

  • Neurogenic Arthrogryposis Multiplex Congenita
  • Myopathic Arthrogryposis Multiplex Congenita
  • Guerin-Stern Syndrome
  • Amyoplasia Congenita

General Discussion

Arthrogryposis Multiplex Congenita, a rare disorder that is present at birth (congenital), is characterized by reduced mobility of many joints of the body. Impairment of mobility is due to the overgrowth (proliferation) of fibrous tissue in the joints (fibrous ankylosis). There are many different types of Arthrogryposis Multiplex Congenita and the symptoms vary widely among affected individuals. In the most common form of Arthrogryposis Multiplex Congenita, the range of motion of the joints in the arms and legs (limbs) is limited or fixed. Other findings may include inward rotation of the shoulders, abnormal extension of the elbows, and bending of the wrists and fingers. In addition, the hips may be dislocated and the heels of the feet may be inwardly bent from the midline of the leg while the feet are inwardly bent at the ankle (clubfoot). The cause of Arthrogryposis Multiplex Congenita (AMC) is unknown. Most types of Arthrogryposis Multiplex Congenita are not inherited; however, a rare autosomal recessive form of the disease has been reported in one large inbred Arabic kindred in Israel.


Human Growth Foundation
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MAGIC Foundation
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Fax: (708)383-0899
Tel: (800)362-4423

P.O. Box 5192
Sonora, CA 95370

Arthrogryposis Group
Beak Cottage
Stourport-on-Severn, Intl DY13 OTZ
United Kingdom
Tel: 01747 822655
Fax: 01747 822655

Arachnoiditis Information and Support Network
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Ontario, M4P 2E5

NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
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Bethesda, MD 20892-3675
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MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
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Tel: (877)336-5333

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see

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