Sarcoidosis

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Sarcoidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Schaumann's Disease
  • Sarcoid of Boeck

Disorder Subdivisions

  • Acute Sarcoidosis; Heerferdt-Waldenstrom and Lofgren's Syndromes (Included)
  • Subacute Sarcoidosis
  • Chronic Sarcoidosis

General Discussion

Sarcoidosis is a multisystem disorder that most often affects individuals between 20 and 40 years of age. Females appear to be affected more frequently than males. Sarcoidosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) consisting of certain granular white blood cells (modified macrophages or epithelioid cells) in certain organs of the body. The granulomas that are formed are thought to alter the normal structure of and, potentially, the normal functions of, the affected organ(s), causing symptoms associated with the particular body system(s) in question. In individuals with sarcoidosis, such granuloma formation most commonly affects the lungs. However, in many cases, the upper respiratory system, lymph nodes, skin, and/or eyes may be involved. In addition, in some cases, other organs may be affected, including the liver, bone marrow, spleen, musculoskeletal system, heart, salivary glands, and/or nervous system (i.e., central or peripheral nervous system).

The range and severity of symptoms associated with sarcoidosis vary greatly, depending upon the specific organ(s) involved and the degree of such involvement. In some cases, the symptoms of sarcoidosis may begin suddenly (acute), sometimes severely, and subside in a relatively short period of time (self limited). Acute sarcoidosis is often characterized by fatigue, fever, generalized muscle aches, difficulty breathing (dyspnea), joint pain, swollen glands, skin eruptions, eye irregularities, and/or other symptoms. In the subacute form, affected individuals may experience no symptoms (asymptomatic), even with organ involvement. In the chronic form of sarcoidosis, symptoms may appear slowly and subtly, and may persist or recur over a long time span. Initial symptoms of the chronic form of the disorder may include difficulty breathing (dyspnea), dry cough, limited airflow, and other respiratory abnormalities. Symptoms associated with other organ involvement may follow.

The exact cause of sarcoidosis is not known. However, possible infectious, environmental, genetic, and immunological factors are under investigation as potential causes of the disorder.
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Resources

American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Avenue
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Internet: http://www.aarda.org/

Sarcoidosis Research Institute
3475 Central Avenue
Memphis, TN 38111
Tel: (901)219-6883
Email: paula@sarcoidosisresearch.org
Internet: http://www.sarcoidosisresearch.org/

American Lung Association
61 Broadway, 6th Floor
New York, NY 10006
USA
Tel: (212)315-8700
Fax: (212)315-8870
Tel: (800)586-4872
Internet: http://www.lungusa.org

NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
1 AMS Circle
Bethesda, MD 20892-3675
USA
Tel: (301)495-4484
Fax: (301)718-6366
Tel: (877)226-4267
TDD: (301)565-2966
Email: NIAMSinfo@mail.nih.gov
Internet: http://www.niams.nih.gov/Health_Info

NIH/National Eye Institute
Building 31 Rm 6A32
31 Center Dr MSC 2510
Bethesda, MD 20892-2510
United States
Tel: (301)496-5248
Fax: (301)402-1065
Email: 2020@nei.nih.gov
Internet: http://www.nei.nih.gov/

NIH/National Heart, Lung and Blood Institute Information Center
P.O. Box 30105
Bethesda, MD 20824-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov

National Sarcoidosis Resource Center
P.O. Box 1593
Piscataway, NJ 08855-1593
Tel: (732)469-4087
Fax: (732)469-4014
Email: sconroy846@aol.com
Internet: http://www.nsrc-global.net

Sarcoidosis Networking Association
6201 Pacific Avenue
Suite B5
Tacoma, WA 98408
Tel: (253)826-7737
Fax: (253)826-7737
Email: sarcoidinformation@sarcoidosisnetwork.org
Internet: http://www.sarcoidosisnetwork.org

Sarcoidosis Online Sites: A Comprehensive Source for Sarcoidosis Information on the Internet
Email: webmaster@sarcoidosisonlinesites.com
Internet: http://www.sarcoidosisonlinesites.com

Sarcoidosis Center
6005 Park Ave
Suite 501
Memphis, TN 38119
USA
Tel: (901)761-5877
Fax: (901)761-2280
Email: sarcoid@sarcoidcenter.com
Internet: http://www.sarcoidcenter.com

Uveitis/OID Support Group
5 Cambridge Center
8th Floor
Cambridge, MA 02142
Tel: (617)621-6377
Fax: (781)431-2042
Tel: (866)353-6377
Email: fosters@comcast.net
Internet: http://www.uveitis.org

Foundation for Sarcoidosis Research
122 South Michigan Avenue, Suite 1700
Chicago, IL 60603
USA
Tel: (312)341-0500
Fax: (312)322-9808
Tel: (866)358-5477
Email: info@stopsarcoidosis.org
Internet: http://www.stopsarcoidosis.org

MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

Erythema Nodosum Yahoo Support Group
Internet: http://health.groups.yahoo.com/group/erythema_nodosum_Group/

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

Jack Miller Center for Peripheral Neuropathy
University of Chicago
5841 South Maryland Ave, MC 2030
Chicago, IL 60637
Tel: (773)702-5800
Fax: (773)702-5577
Internet: http://millercenter.uchicago.edu

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

Autoimmune Information Network, Inc
PO Box 4121
Brick, NJ 08723
Tel: (732)664-9259
Email: autoimmunehelp@aol.com
Internet: http://www.aininc.org

European Society for Immunodeficiencies (ESID)
c/o Dr. Bodo Grimbacher (ESID Board Member)
Division of Rheumatology and Clinical Immunology
Department of Medicine, University Hospital Freiburg
Hugstetter Strasse 55
Freiburg, D-79106
Germany
Tel: +31 73-6992965
Fax: +31 73-6992948
Email: info@esid.org
Internet: http://www.esid.org

Janine Sarcoidosis Outreach Foundation
12600 Bissonnet
A4
Houston, TX 77099
Tel: (832)248-6621
Fax: (281)568-5775
Tel: (800)846-5158
Email: sarcoidosis@jsof.org
Internet: http://www.jsof.org/

AutoImmunity Community
Tel: (919) 552-9057
Email: bandrews@autoimmunitycommunity.org
Internet: http://autoimmunitycommunity.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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