Idiopathic Thrombocytopenic Purpura

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Idiopathic Thrombocytopenic Purpura is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • ITP
  • Purpura Hemorrhagica ITP
  • Werlhof disease

Disorder Subdivisions

  • None

General Discussion

Idiopathic thrombocytopenic purpura (ITP) is a rare autoimmune bleeding disorder characterized by the abnormally low levels of certain blood cells called platelets, creating a condition known as thrombocytopenia. Platelets are specialized blood cells that help prevent and stop bleeding by inducing clotting. In ITP, there is no readily apparent cause or underlying disease (idiopathic). The cells of the immune system, lymphocytes, produce anti-platelet antibodies that attach to the platelets. The presence of antibodies on platelets leads to their destruction in the spleen. The disorder is characterized by abnormal bleeding into the skin resulting in bruising, which is what the term purpura means. Bleeding from mucous membranes also occurs, and may subsequently result in low levels of circulating red blood cells (anemia).

ITP presents as a brief, self-limiting form of the disorder (acute ITP) or a longer-term form (chronic ITP). Acute ITP accounts for about 90% of cases, and chronic ITP accounts for the remainder. Eighty percent (80%) of the children with ITP have the acute form while the chronic form affects mostly adults. The acute form usually resolves without treatment (spontaneously) within three to six months. When thrombocytopenia lasts for more than six to 12 months, ITP is classified as the chronic form. Onset of acute ITP is often rapid, while the onset of the chronic form may be gradual.

Resources

American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Avenue
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Internet: http://www.aarda.org/

ITP Society of the Children's Blood Foundation
333 East 38th Street
Suite 830
New York, NY 10016
Tel: (212)297-4336
Fax: (212)888-7724
Tel: (800)487-7010
Email: info@childrenscbf.org
Internet: http://www.childrensbloodfoundation.org/

NIH/National Heart, Lung and Blood Institute Information Center
P.O. Box 30105
Bethesda, MD 20824-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov

ITP People Place
133 Rollins Avenue, #5
Rockville, MD 20852
USA
Tel: (301)770-6636
Fax: (301)770-6638
Tel: (877)528-3538
Email: info@pdsa.org
Internet: http://www.pdsa.org/

NIH/Hematology Branch, National Heart, Lung and Blood Institute (NHLBI)
10 Center Dr, Building 10-CRC
3-5140, MSC-1202
Bethesda, MD 20892-1202
Tel: (301)402-0764
Fax: (301)402-3088
Email: zamaniw@nhlbi.nih.gov
Internet: http://dir.nhlbi.nih.gov/labs/hb/index.asp?

Platelet Disorder Support Association
133 Rollins Avenue
Suite 5
Rockville, MD 20852
USA
Tel: (301)770-6636
Fax: (301)770-6638
Tel: (877)528-3538
Email: pdsa@pdsa.org
Internet: http://www.pdsa.org

MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

ITP Foundation
30 Old Kings Hwy South Suite 275
Darien, CT 06820
USA
Tel: (203)655-6954
Fax: (203)548-9182
Email: itpf@itpfoundation.org
Internet: http://www.itpfoundation.org

ITP Support Association
Synehurst, Kimbolton Road
Bolnhurst, Beds, MK44 2EW
United Kingdom
Tel: 01144 0870 777 0559
Fax: 01144 0870 777 0559
Email: shirley@itpsupport.org.uk
Internet: http://www.itpsupport.org.uk

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

Autoimmune Information Network, Inc
PO Box 4121
Brick, NJ 08723
Tel: (732)664-9259
Email: autoimmunehelp@aol.com
Internet: http://www.aininc.org

European Society for Immunodeficiencies (ESID)
c/o Dr. Bodo Grimbacher (ESID Board Member)
Division of Rheumatology and Clinical Immunology
Department of Medicine, University Hospital Freiburg
Hugstetter Strasse 55
Freiburg, D-79106
Germany
Tel: +31 73-6992965
Fax: +31 73-6992948
Email: info@esid.org
Internet: http://www.esid.org

AutoImmunity Community
Tel: (919) 552-9057
Email: bandrews@autoimmunitycommunity.org
Internet: http://autoimmunitycommunity.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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