Nephrogenic Diabetes Insipidus
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Nephrogenic Diabetes Insipidus is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Acquired Nephrogenic Diabetes Insipidus
- Congenital Nephrogenic Diabetes Insipidus
- Vasopressin-Resistant Diabetes Insipidus
- Hereditary Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus (NDI) is a rare kidney disorder that may be inherited or acquired. NDI is not related to the more common diabetes mellitus (sugar diabetes), in which the body does not produce or properly use insulin. NDI is a distinct disorder caused by complete or partial resistance of the kidneys to arginine vasopressin (AVP). Vasopressin is an antidiuretic hormone used by the kidney to manage water balance in the body. NDI causes chronic excessive thirst (polydipsia), excessive urine production (polyuria), and potentially dehydration. If left untreated, repeated episodes of severe dehydration may develop, eventually resulting in serious complications. Most cases of hereditary NDI are inherited as an X-linked recessive trait. Rare cases are inherited as an autosomal recessive or dominant trait. Two different genes have been identified that cause hereditary NDI.
NDI may also be acquired during life as a result of drug use (e.g.,lithium therapy), kidney disease, obstruction of the tubes that carry urine from the kidneys to the bladder (ureters), and prolonged metabolic imbalances such as low levels of potassium in the blood (hypokalemia) or low levels of calcium in the blood (hypocalcemia). NDI may also be a complication associated with pregnancy.
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Diabetes Insipidus Foundation, Inc.
c/o Mike Gandrud
1232 24th Street
Ames, IA 50010
NIH/National Diabetes Information Clearinghouse
1 Information Way
Bethesda, MD 20892-3560
Nephrogenic Diabetes Insipidus Foundation
PO Box 1390
Eastsound, WA 98245
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
PO Box 241956
Los Angeles, CA 90024
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