National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Myasthenia Gravis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Generalized myasthenia gravis
- Ocular myasthenia gravis
- Familial Infantile (Congenital) Myasthenia Gravis
- Congenital Myasthenia Gravis
- Transient Neonatal Myasthenia Gravis
Myasthenia gravis is a neuromuscular disorder primarily characterized by muscle weakness and muscle fatigue. Although the disorder usually becomes apparent during adulthood, symptom onset may occur at any age. The condition may be restricted to certain muscle groups, particularly those of the eyes (ocular myasthenia gravis), or may become more generalized (generalized myasthenia gravis), involving multiple muscle groups.
Most individuals with myasthenia gravis develop weakness and drooping of the eyelids (ptosis); weakness of eye muscles, resulting in double vision (diplopia); and excessive muscle fatigue following activity. Additional features commonly include weakness of facial muscles; impaired articulation of speech (dysarthria); difficulties chewing and swallowing (dysphagia); and weakness of the upper arms and legs (proximal limb weakness). In addition, in about 10 percent of cases, affected individuals may develop potentially life-threatening complications due to severe involvement of muscles used during breathing (myasthenic crisis).
Myasthenia gravis results from an abnormal immune reaction in which the body's natural immune defenses (i.e., antibodies) inappropriately attack and gradually destroy certain receptors in muscles that receive nerve impulses (antibody-mediated autoimmune response).
Myasthenia Gravis Foundation of America
355 Lexington Avenue, 15th Floor
New York, NY 10017
American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Avenue
Eastpointe, MI 48021
Muscular Dystrophy Association
3300 E. Sunrise Dr
Tucson, AZ 85718
National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
Myasthenia Gravis Links
Web Site on the Internet
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
New Horizons Un-Limited, Inc.
811 East Wisconsin Ave
Milwaukee, WI 53202
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Autoimmune Information Network, Inc
PO Box 4121
Brick, NJ 08723
European Society for Immunodeficiencies (ESID)
c/o Dr. Bodo Grimbacher (ESID Board Member)
Division of Rheumatology and Clinical Immunology
Department of Medicine, University Hospital Freiburg
Hugstetter Strasse 55
Tel: +31 73-6992965
Fax: +31 73-6992948
Tel: (919) 552-9057
For a Complete Report
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html