Tooth and Nail Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Tooth and Nail Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Tooth and nail syndrome is a rare genetic disorder that belongs to a group of diseases known as ectodermal dysplasia, which group consists of more than 100 separate recognized syndromes. Ectodermal dysplasias typically affect the teeth, nails, hair, and/or skin. Tooth and nail syndrome is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development (dysplasia) of the nails, particularly the toenails.
In individuals with Tooth and nail syndrome, certain primary teeth and/or several secondary teeth may either be absent or widely spaced and/or conical in shape (coniform). In addition, the nails in young children with the disorder, especially the toenails, may be unusually small and underdeveloped (hypoplastic), with distinctive, abnormal hollowing causing them to appear to be spoon-shaped. Tooth and nail syndrome is inherited as an autosomal dominant genetic trait.
National Foundation for Ectodermal Dysplasias
410 East Main Street
PO Box 114
Mascoutah, IL 62258-0114
NIH/National Institute of Dental and Craniofacial Research
NIH/National Oral Health Information Clearinghouse
1 NOHIC Way
Bethesda, MD 20892-3500
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
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