Hyperlipoproteinemia Type IV

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Hyperlipoproteinemia Type IV is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Carbohydrate-Induced Hyperlipemia
  • Hypercholesterolemia, Type IV
  • Hyperlipidemia IV
  • Hyperprebeta-Lipoproteinemia
  • Hypertriglyceridemia, Endogenous

Disorder Subdivisions

  • None

General Discussion

Hyperlipoproteinemia Type IV is a not uncommon inherited metabolic disorder that is characterized by increased blood levels of the triglyceride form of fat that makes up very low-density lipids (VLDL). Abnormally high blood levels of triglycerides or cholesterol (another form of blood plasma fat) may be the result of poor dietary habits, genetic causes, or other metabolic disorders or a side effect of certain drugs.

Hyperlipoproteinemia Type IV is one of a family of five types of hyperlipoproteinemia, which is an indicator of a risk of heart disease. Each of types I through IV presents a different profile of blood fat and a different set of associated risks of heart disease.

Hyperlipoproteinemia and hyperlipidemia are synonymous. Both refer to an excess of fatty substances (lipids) in the blood. The condition may also be called hyperlipoproteinemia because the fats are transported through the blood as attachments to specialized proteins. These fat-protein complex molecules are called lipoproteins, among which the better known are HDL (high density lipoprotein, LDL (low density lipoprotein), and VLDL (very low density lipoprotein).

Studies have shown that the risk of heart disease is directly proportional to the blood level of a complex chemical called LDL-cholesterol and inversely proportional to the blood level of HDL-cholesterol. If the blood level of LDL is high, then the risk of heart disease is also high. However, if the blood level of HDL is high, the risk of heart disease is correspondingly low.

Hyperlipoproteinemia Type IV is common and frequently runs in families; i.e. it is genetic in origin. It is characterized by high blood triglyceride levels and obesity, usually with mild diabetes.

For a very brief review of each of the other hyperlipoproteinemias. see the Related Disorders section of this report.
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Resources

American Heart Association
7272 Greenville Avenue
Dallas, TX 75231-4596
Tel: (214)373-6300
Fax: (214)373-0268
Tel: (800)242-8721
Email: Review.personal.info@heart.org
Internet: http://www.americanheart.org

NIH/National Heart, Lung and Blood Institute Information Center
P.O. Box 30105
Bethesda, MD 20824-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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