Colitis, Collagenous

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Colitis, Collagenous is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Microscopic Colitis, Collagenous Type

Disorder Subdivisions

  • None

General Discussion

Collagenous colitis is a rare digestive disorder that primarily affects females and typically becomes apparent during middle age. The disorder is characterized by inflammatory changes of the mucous membranes (mucosa) of the colon (colitis) and abnormal accumulation (excessive deposition) of the protein collagen beneath the surface (epithelial) layer of the mucosa (thickened subepithelial collagenous bands). The colon is the major portion of the large intestine. The medical literature often refers to collagenous colitis as a form of "microscopic colitis," since evidence of inflammation and other abnormalities may only be confirmed through microscopic (i.e., histologic) examination of multiple tissue samples.

Individuals with collagenous colitis typically experience episodes of chronic, watery, nonbloody diarrhea. In some instances, episodes may often occur at night (nocturnal diarrhea). Diarrheal episodes may be persistent or may occur at intervals (intermittent) over a period of weeks, months, or years. Other symptoms and findings that may occasionally be associated with such episodes include vague abdominal pain, abdominal swelling (distension), nausea, vomiting, and/or weight loss.

The exact cause of collagenous colitis is unknown. Possible immunological, environmental, genetic, and/or other factors are under investigation as potential causes of the disorder.
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Resources

Crohn's and Colitis Foundation of America
386 Park Avenue South
17th Floor
New York, NY 10016-9804
USA
Tel: (212)685-3440
Fax: (212)779-4098
Tel: (800)932-2423
Email: info@ccfa.org
Internet: http://www.ccfa.org

Digestive Disease National Coalition
507 Capitol Court, NE
Suite 200
Washington, DC 20002
Tel: (202)544-7497
Fax: (202)546-7105
Email: ddnc@hmcw.org
Internet: http://www.ddnc.org

NIH/National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892-3570
Tel: (301)654-3810
Fax: (301)907-8906
Tel: (800)891-5389
Email: nddic@info.niddk.nih.gov
Internet: http://www.niddk.nih.gov

International Foundation for Functional Gastrointestinal Disorders
P.O. Box 170864
Milwaukee, WI 53217
USA
Tel: (414)964-1799
Fax: (414)964-7176
Tel: (888)964-2001
Email: iffgd@iffgd.org
Internet: http://www.iffgd.org

Gastro-Intestinal Research Foundation
70 East Lake Street
Suite 1015
Chicago, IL 60601-5907
Tel: (312)332-1350
Fax: (312)332-4757
Email: info@girf.org
Internet: http://www.girf.org

Reach Out for Youth with Ileitis and Colitis, Inc.
PO Box 857
Bellmore, NY 11710
USA
Tel: (631)293-3102
Email: info@reachoutforyouth.org
Internet: http://www.reachoutforyouth.org

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

CORE
3 St. Andrews Place
London, NW1 4LB
UK
Tel: 020 7486 0341
Fax: 020 7224 2012
Email: info@corecharity.org.uk
Internet: http://www.corecharity.org.uk

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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