Primary Lateral Sclerosis

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Primary Lateral Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Central Motor Neuron Disease
  • PLS

Disorder Subdivisions

  • None

General Discussion

Primary lateral sclerosis (PLS) is a rare, neuromuscular disorder that affects the central motor neurons and is characterized by painless but progressive weakness and stiffness of the muscles of the legs. Such weakness may progress to affect the arms and the muscles at the base of the brain (bulbar muscles). Less frequently, the muscles of the face are affected. In most cases, the disorder affects adults during midlife. The exact cause of primary lateral sclerosis is unknown.
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Resources

Amyotrophic Lateral Sclerosis Association
27001 Agoura Road
Suite 150
Calabasas Hills, CA 91301-5104
USA
Tel: (818)880-9007
Fax: (818)880-9006
Tel: (800)782-4747
TDD: (818)593-3540
Email: als@alsa-national.org
Internet: http://www.alsa.org

Motor Neurone Disease Association
P.O. Box 246
Northampton, Intl NN1 2PR
United Kingdom
Tel: 44 1604 250505
Fax: 44 1604 624726
Email: enquiries@mndassociation.org
Internet: http://www.mndassociation.org

National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Email: me20t@nih.gov
Internet: http://www.ninds.nih.gov/

Les Turner Amyotrophic Lateral Sclerosis Foundation, Ltd.
5550 W. Touhy Avenue, Suite 302
Skokie, IL 60077-3254
Tel: (847)679-3311
Fax: (847)679-9109
Tel: (888)257-1107
Email: info@lesturnerals.org
Internet: http://www.lesturnerals.org

International Alliance of ALS/MND Associations
P.O. Box 246
Northampton, NN1 2PR
United Kingdom
Email: alliance@alsmndalliance.org
Internet: http://www.alsmndalliance.org/

Connecticut Connection
530 Silas Deane Highway (Rt. 99)
Wethersfield, CT 06109
USA
Tel: (860)529-8006
Fax: (860)677-4754
Email: hartford@ctconnection.com
Internet: http://www.ctconnection.com/

Spastic Paraplegia Foundation
212 Farm Rd
Woburn, MA Sherborn
USA
Tel: (877)773-4483
Email: info@sp-foundation.org
Internet: http://sp-foundation.org

MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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