Motor Neuron Disease

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Motor Neuron Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Motoneuron Disease
  • Motoneurone Disease
  • Motor Neuron Syndrome
  • Motor Neurone Disease

Disorder Subdivisions

  • Progressive Bulbar Palsy
  • Amyotrophic Lateral Sclerosis
  • Spinal Muscular Atrophy, All Types
  • Kugelberg-Welander Syndrome
  • Lou Gehrig's Disease, Included
  • Duchenne's Paralysis
  • Werdnig-Hoffmann Disease
  • Juvenile Spinal Muscular Atrophy
  • ALS Included
  • Benign Focal Amyotrophy
  • Infantile Spinal Muscular Atrophy (all types)

General Discussion

Motor neuron disease comprises a group of severe disorders of the nervous system characterized by progressive degeneration of motor neurons (neurons are the basic nerve cells that combine to form nerves). Motor neurons control the behavior of muscles. Motor neuron diseases may affect the upper motor neurons, nerves that lead from the brain to the medulla (a part of the brain stem) or to the spinal cord, or the lower motor neurons, nerves that lead from the spinal cord to the muscles of the body, or both. Spasms and exaggerated reflexes indicate damage to the upper motor neurons. A progressive wasting (atrophy) and weakness of muscles that have lost their nerve supply indicate damage to the lower motor neurons.

Resources

Amyotrophic Lateral Sclerosis Association
27001 Agoura Road
Suite 150
Calabasas Hills, CA 91301-5104
USA
Tel: (818)880-9007
Fax: (818)880-9006
Tel: (800)782-4747
TDD: (818)593-3540
Email: als@alsa-national.org
Internet: http://www.alsa.org

Families of Spinal Muscular Atrophy
925 Busse Road
Elk Grove Village, IL 60007
Tel: (847)367-7620
Fax: (847)367-7623
Tel: (800)886-1762
Email: sma@fsma.org
Internet: http://www.curesma.com

Motor Neurone Disease Association
P.O. Box 246
Northampton, Intl NN1 2PR
United Kingdom
Tel: 44 1604 250505
Fax: 44 1604 624726
Email: enquiries@mndassociation.org
Internet: http://www.mndassociation.org

Muscular Dystrophy Association
3300 E. Sunrise Dr
Tucson, AZ 85718
USA
Tel: (520)529-2000
Fax: (520)529-5300
Tel: (800)572-1717
Email: mda@mdausa.org
Internet: http://www.mda.org/

National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Email: me20t@nih.gov
Internet: http://www.ninds.nih.gov/

International Alliance of ALS/MND Associations
P.O. Box 246
Northampton, NN1 2PR
United Kingdom
Email: alliance@alsmndalliance.org
Internet: http://www.alsmndalliance.org/

Scottish Motor Neurone Disease Association
76 Firhill Rd
Glasgow, Intl G20 7BA
Scotland
Tel: 01419451077
Fax: 01419452578
Email: info@scotmnd.co.uk
Internet: http://www.scotmnd.org.uk

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

Association for Frontotemporal Dementias (AFTD)
1616 Walnut Street, Suite 1100
Philadelphia, PA 19103
Tel: (267)514-7221
Tel: (866)507-7222
Email: info@ftd-picks.org
Internet: http://www.ftd-picks.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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