Neuroleptic Malignant Syndrome

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Neuroleptic Malignant Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Drug-Induced Movement Disorder
  • Neuroleptic-Induced Acute Dystonia
  • Hyperthermia

Disorder Subdivisions

  • None

General Discussion

Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.

The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.

A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.

Resources

Malignant Hyperthermia Association of the United States (MHAUS)
11 East State Street
PO Box 1069
Sherburne, NY 13460-1069
USA
Tel: (607)674-7901
Fax: (607)674-7910
Email: info@mhaus.org
Internet: http://www.mhaus.org

North American Malignant Hyperthermia Registry of MHAUS
Children's Hospital of Pittsburgh
Room #7446
3705 Fifth Ave at DeSoto St
Pittsburgh, PA 15213-2583
USA
Tel: (412)692-6390
Fax: (412)692-8658
Tel: (888)274-7899
Email: bwb+@pitt.edu
Internet: http://www.mhreg.org

National Mental Health Consumers' Self-Help Clearinghouse
1211 Chestnut Street
Suite 1207
Philadelphia, PA 19107-6312
USA
Tel: (215)751-1810
Fax: (215)636-6312
Tel: (800)553-4539
Email: info@mhselfhelp.org
Internet: http://www.mhselfhelp.org

National Mental Health Association
2000 North Beauregard Street
6th Floor
Alexandria, VA 22311
USA
Tel: (703)684-7722
Fax: (703)684-5968
Tel: (800)969-6642
TDD: (800)433-5959
Email: infoctr@nmha.org
Internet: http://www.nmha.org

National Alliance for the Mentally Ill
Colonial Place Three
2107 Wilson Blvd.
Suite 300
Arlington, VA 22201-3042
Tel: (703)524-7600
Fax: (703)524-9094
Tel: (800)999-6264
TDD: (703)516-7227
Email: membership@nami.org
Internet: http://www.nami.org

NIH/National Institute of Mental Health
6001 Executive Blvd
Rm 8184, MSC 9663
Rockville, MD 20892-9663
Tel: (301)443-4513
Email: nimhinfo@nih.gov
Internet: http://www.nimh.nih.gov/

MedicAlert Foundation International
2323 Colorado Avenue
Turlock, CA 95382
USA
Tel: (209)669-2401
Fax: (209)669-2456
Tel: (888)633-4298
Email: Inquiries@medicalert.org
Internet: http://www.medicalert.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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