Progressive Myoclonus Epilepsy

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Progressive Myoclonus Epilepsy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Myoclonic Epilepsy
  • Myoclonic Progressive Familial Epilepsy
  • Myoclonus Epilepsy
  • Progressive Familial Myoclonic Epilepsy
  • Epilepsy, Myoclonic Progressive Familial

Disorder Subdivisions

  • Myoclonic Epilepsy, Hartung Type
  • Lafora Disease, Included
  • Baltic Myoclonus Epilepsy
  • Lafora Body Disease
  • Unverricht Disease
  • Unverricht-Lundborg Disease
  • Lundborg-Unverricht Disease, Included

General Discussion

Progressive myoclonus epilepsy (PME) is a group of conditions involving the central nervous system and representing more than a dozen different diseases. These diseases share certain features, including a worsening of symptoms over time and the presence of both muscle contractions (myoclonus) and seizures (epilepsy). Patients may have more than one type of seizure, such as petit mal or grand mal. PME is progressive, but the rate of progression may be quick or slow, depending on the underlying disease.

Progressive myoclonus epilepsy (PME) is different from myoclonic epilepsy. In myoclonic epilepsy, the myoclonic jerking motions occur as part of the seizure. In PME, myoclonus occurs separately from seizures, the two respond differently to the same drugs, they evolve differently during the natural history of the disease, and they cause different problems for the patient. Some drugs that are good for seizures, e.g. phenytoin and carbamazepine, may tend to make the myoclonus worse.

Resources

Epilepsy Foundation
8301 Professional Place
Landover, MD 20785
Tel: (301)459-3700
Fax: (301)577-2684
Tel: (800)332-1000
TDD: (800)332-2070
Email: info@efa.org
Internet: http://www.epilepsyfoundation.org

National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Email: me20t@nih.gov
Internet: http://www.ninds.nih.gov/

National Pediatric Myoclonus Center
SIU School of Medicine
Dept. of Neurology, Div. of Ped. Neurology
PO Box 19643
Springfield, IL 62794-9643
USA
Tel: (217)545-7635
Fax: (217)545-1903
Email: oms@siumed.edu
Internet: http://www.omsusa.org

Epilepsy Canada
2255B Queen St E, Suite 336
Toronto
Ontario, M4E 1G3
Canada
Tel: (877) 734-0873
Fax: (905) 764-1231
Tel: 8777340873
Email: epilepsy@epilepsy.ca
Internet: http://www.epilepsy.ca

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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