Malignant Hyperthermia

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Malignant Hyperthermia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Hyperpyrexia

Disorder Subdivisions

  • None

General Discussion

Malignant Hyperthermia (MH) is a pharmacogenetic channelopathy affecting skeletal muscle. When MH-susceptible individual are given potent inhalational agents (halothane, sevoflurane, desflurane, etc.) and/or succinylcholine, they can develop a hypermetabolic state that can rapidly progress to a high temperature, muscle rigidity, cardiac arrest, and ultimately may lead to death.

Resources

Malignant Hyperthermia Association of the United States (MHAUS)
11 East State Street
PO Box 1069
Sherburne, NY 13460-1069
USA
Tel: (607)674-7901
Fax: (607)674-7910
Email: info@mhaus.org
Internet: http://www.mhaus.org

North American Malignant Hyperthermia Registry of MHAUS
Children's Hospital of Pittsburgh
Room #7446
3705 Fifth Ave at DeSoto St
Pittsburgh, PA 15213-2583
USA
Tel: (412)692-6390
Fax: (412)692-8658
Tel: (888)274-7899
Email: bwb+@pitt.edu
Internet: http://www.mhreg.org

Neuroleptic Malignant Syndrome Information Service
Box 1069
Sherburne, NY 13460-1069
United States
Tel: (607)674-7920
Fax: (607) 674-7910
Tel: (888) 667-8367
Email: info@nmsis.org
Internet: http://www.nmsis.org/

NIH/National Institute of General Medical Sciences
45 Center Dr MSC 6200
Bethesda, MD 20892-6200
Tel: (301)496-7301
Fax: (301)402-0224

Malignant Hyperthermia Investigation Unit
Toronto General Hospital
200 Elizabeth Street
CCRW-2, Room ES3-403A
Toronto
Ontario, Intl M5G 2C4
Canada
Tel: (416)340-3128
Fax: (416)340-4960
Email: info@mhacanada.org
Internet: http://www.mhacanada.org

MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: mums@netnet.net
Internet: http://www.netnet.net/mums/

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Email: ordr@od.nih.gov
Internet: http://rarediseases.info.nih.gov/Default.aspx

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

For a Complete Report

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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