National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Laron Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Growth Hormone Binding Protein Deficiency or Dysfunction
- Growth Hormone Receptor Deficiency or Dysfunction
- Laron Type Pituitary Dwarfism I
- Pituitary Dwarfism II
- Laron Dwarfism
Laron syndrome type I (LTD1) a rare genetic disorder, is caused by the body's inability to use the growth hormone (GH) that it produces. The problem lies not in the production of growth hormone but rather in a defective GH-receptor gene. This defect prevents the proper binding of the GH molecule, leaving high levels of unbound growth hormone in the plasma.
Laron syndrome is characterized by short stature and delayed bone age, as well as high levels of circulating growth hormone.
A second form of the disorder known as Laron syndrome type II (LTD2) shows typical clinical features of the Laron syndrome but is due to a defect in the biochemical processing of growth hormone after the hormone has been bound on the cell surface.
Human Growth Foundation
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Glen Head, NY 11545
6645 W. North Avenue
Oak Park, IL 60302
Little People's Research Fund, Inc.
616 Old Edmondson Avenue
Catonsville, MD 21228-3305
Little People of America, Inc.
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Tustin, CA 92780
MUMS National Parent-to-Parent Network
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Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
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