Autoimmune Polyendocrine Syndrome Type II
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Autoimmune Polyendocrine Syndrome Type II is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Diabetes Mellitus, Addison's Disease, Myxedema
- Multiple Endocrine Deficiency Syndrome, Type II
- PGA II
- Polyglandular Autoimmune Syndrome, Type II
- Polyglandular Deficiency Syndrome, Type II
- Schmidt Syndrome
Autoimmune polyendocrine syndrome type II, also known as Schmidt syndrome, is a rare autoimmune disorder in which there is a steep drop in production of several essential hormones by the glands that secrete these hormones. When first described, this disorder was thought to involve only adrenal insufficiency (Addison's disease) and thyroid insufficiency (Hashimoto's thyroiditis). However, over time, as more patients were studied, the scope of the disorder was expanded to include disorders of other underperforming endocrine glands. These include the gonads, which secrete sex hormones; the pancreas which secretes insulin and is intimately tied up with diabetes mellitus; and sometimes the parathyroid glands. Failure of the endocrine glands to function is usually accompanied by signs of malnutrition because the ability of the intestinal tract to absorb nutrients is reduced dramatically. Since the combination of affected glands differs from patient to patient, the signs of this disorder are diverse.
Most cases of this disorder are sporadic although some clinical researchers believe that there is a familial or hereditary trait associated with AIPS-II. If so, it may involve a complex interaction among many genes.
Myasthenia Gravis Foundation of America
355 Lexington Avenue, 15th Floor
New York, NY 10017
National Adrenal Diseases Foundation
505 Northern Boulevard
Great Neck, NY 11021
American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Avenue
Eastpointe, MI 48021
Celiac Sprue Association/USA, Inc.
P.O. Box 31700
Omaha, NE 68131-0700
American Diabetes Association
Attn: National Call Center
1701 N. Beauregard Street
Alexandria, VA 22311
NIH/National Digestive Diseases Information Clearinghouse
2 Information Way
Bethesda, MD 20892-3570
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (919) 552-9057
For a Complete Report
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html