St. John's wort

St. John's wort (Hypericum perforatum) is a plant with yellow flowers that has been used to treat depression in European countries for centuries. It is sold in liquid and powder (pill) form and can be found at health food stores and pharmacies.

A person who wants to try St. John's wort should first talk to his or her doctor because it may interfere with treatment for other conditions. Also, herbal products are not regulated in the United States, so ingredients and quality can be inconsistent.

A person should not take St. John's wort while taking:

  • Other antidepressants. Taking both can result in serious, negative side effects.
  • Protease inhibitors (PIs) or nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infection.

Last Updated: June 30, 2009

Author: Eileen Ellig & Jeannette Curtis

Medical Review: Kathleen Romito, MD - Family Medicine & Marc S. Micozzi, MD, PhD - Complementary and Alternative Medicine

related physicians

related services

Bon Secours International| Sisters of Bon Secours USA| Bon Secours Health System

This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Privacy Policy. How this information was developed to help you make better health decisions.

© 1995-2010 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.