Intraventricular hemorrhage in premature infants

During the first week after birth, some premature infants develop bleeding in the brain (intraventricular hemorrhage), for which there is no known treatment. Bleeding severity is most often minimal (grades I and II) and causes little or no noticeable brain damage. Grade III bleeding raises the risk of developing hydrocephalus (a buildup of excess cerebrospinal fluid within the brain), brain damage, or both. Grade IV is used to describe extensive bleeding that has damaged brain tissue and shows up on image tests.

The more immature the brain, the more fragile the brain's blood vessels and the more sensitive they are to changes in blood pressure. So extremely premature infants are at the greatest risk for intraventricular hemorrhage.

Regardless of an infant's gestational age at birth, the risk of intraventricular hemorrhage drops significantly after the first 72 hours of life and is negligible after 7 days of age. Very premature infants typically have an ultrasound of the head (cranial ultrasound) 3 to 7 days after birth to check for intraventricular hemorrhage. Those who show signs of bleeding are periodically checked thereafter.

Prevention measures that can reduce the risk of intraventricular hemorrhage include:1

  • Corticosteroid treatment, given to the mother before the birth. This treatment is typically given to help fetal lungs develop before a premature birth and is thought to make blood vessels less likely to bleed.
  • Indomethacin, given to the infant after birth. This nonsteroidal anti-inflammatory drug (NSAID) tightens the brain's blood vessels (vasoconstriction), which helps control sudden changes in blood pressure in the brain.


  1. Thilo EH, Rosenberg AA (2009). The preterm infant and the late preterm infant sections of The newborn infant. In WW Hay et al., eds., Current Diagnosis and Treatment: Pediatrics, 19th ed., pp. 30–41. New York: McGraw-Hill.

Last Updated: May 5, 2009

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